Riaan Amanethiwekhi e-Neural asize ososayensi ukuba bakhe isibulala-magciwane esikwazi ukulwa ne-superbug emelana kakhulu evame ukutholakala ezibhedlela.
Isiphazamisi sibizwa I-Acinetobacter baumannii futhi iyakhohlisa.
“I-Acinetobacteria ingaphila ngezinsimbi zeminyango yasesibhedlela kanye nemishini isonto noma ngaphezulu, futhi ingathatha izakhi zofuzo zokumelana nama-antibiotic endaweni yayo,” kusho Jonathan Stokes, uprofesa osizayo we-biochemistry kanye ne-biomedical science eMcMaster University. “Sekuyinsakavukela umchilo wesidwaba manje ukuthola A. baumanii ama-isolates amelana cishe nawo wonke ama-antibiotic.”
UStokes kanye nozakwabo eMcMaster University kanye neMIT baphendukela ku-AI ukuze babone izinhlanganisela ezingalwa ne-microbe. Okokuqala, badalula ama-molecule angu-7,500 ahlukene ohlotsheni lwamabhaktheriya akhule esitsheni selebhu ukuze babone ukuthi azokuvimbela yini ukukhula kwawo. Basebenzise leyo dathasethi ukuze baqeqeshe isigaba sokufunda somshini ukuze bafunde ukuthi yiziphi izici zamakhemikhali ezihlanganisweni ezinikeze amagciwane usizi.
Imodeli yabe isisetshenziselwa ukuhlaziya idathasethi entsha ehlanganisa amakhomponi ayi-6,680 eyayingakaze ibonwe ngaphambili, ukubikezela ukuthi bangase benze ama-antibiotics athembisayo.
Isoftware ikhombe amakhulu abantu abazongenela ukhetho emahoreni amabili nje kuphela okusebenza, futhi abacwaningi bakhethe abangama-240 ukuze baqhubeke nokuhlola.
Leyo nqubo yagcina ikhiqize ama-antibiotics ayisishiyagalolunye, anenhlanganisela ebizwa ngokuthi “abaucin” etholakala iphumelela kakhulu ekulweni A. baumanii.
I-Abaucin yafundwa ngaphambili njengesidakamizwa esingaba khona isifo sikashukela. Manje imakwe njenge A. baumanii-umzingeli ohlasela ngokukhetha i-superbug.
Ukuhlolwa kokuqala nge-abaucin kumagundane kubonise ukuthi ingacindezela izifo zezilonda ezibangelwa A. baumanii. Imiphumela yaba eshicilelwe phakathi ku I-Nature Chemical Biology iphepha ngoLwesine.
Abacwaningi baqaphele ukuthi i-abaucin ayisebenzi njengemithi elwa namagciwane evamile, kodwa ngoba A. baumanii isithuthuke ukumelana nokwelashwa okuvamile, inhlanganisela ekhonjwe yi-AI ingamela isigaba esisha semithi elwa namagciwane ukukhomba isinambuzane.
“Yonke idatha yethu yokuhlola iphakamisa ukuthi i-abaucin ivimbela inqubo yezinto eziphilayo A baumanii okubizwa nge-lipoprotein trafficking, okuyindlela engajwayelekile phakathi kwama-antibiotic asetshenziswa emtholampilo,” kusho uStokes. Irejista. “Okwamanje sigxile ekwenzeni ama-analogue esakhiwo se-abaucin ukuze sithuthukise izakhiwo zayo zokwelapha ukuze kwandiswe amathuba okuthi i-abaucin – noma i-analogue ye-abaucin – ingaba umuthi wokulwa namagciwane wokulwa. A baumanii izifo.”
Uthe ucwaningo lukhombisa ukuthi i-AI ingaba yithuluzi elinamandla lokutholwa kwezidakamizwa. “Singakwazi ukukhombisa lezi zinhlobo izinombolo eziningi zamakhemikhali bese amamodeli bese esitshela ukuthi yimaphi amakhemikhali anempahla esiyikhathalelayo. Singabe sesigxila isikhathi sethu nezinsiza ekuhloleni amakhemikhali athembisa kakhulu njengoba kuphakanyiswe imodeli ye-AI. I-AI yenza iziphakamiso. . Abantu bayazenza izinqumo,” wasitshela.
UJames Collins, umbhali ohlangene wocwaningo kanye noprofesa wobunjiniyela bezokwelapha ohola i-MIT’s Abdul Latif Jameel Clinic for Machine Learning in Health, wavuma esitatimendeni: “Izindlela ze-AI zokutholwa kwezidakamizwa zilapha ukuze zihlale futhi zizoqhubeka zicwengisiswa. Siyazi ukuthi amamodeli we-algorithmic ayasebenza, manje kuyindaba yokwamukela kabanzi lezi zindlela zokuthola ama-antibiotic amasha ngendlela ephumelelayo futhi engabizi kakhulu.” ®
